PharmaceuticalFoodPersonal Care
Japanese

Hydroxypropyl cellulose

Hydroxpropyl cellulose

Grades & Availability

NISSO HPC SSL SL L LM LMM M H VH
Viscosity mPa·s @20˚C/ 2%aq 2~2.9 3~5.9 6~10 11~20 21~50 150~400 1000~4000 4001~6000
Molecular Weight /GPC method ~40,000~ ~100,000~ ~140,000~ ~180,000~ ~280,000~ ~620,000~ ~910,000~ ~2,500,000~
UNII 8VAB711C5E 66O7AQV0RT UKE75GEA7F 5Y0974F5PW 5Y0974F5PW U3JF91U133 RFW2ET671P RFW2ET671P

Availability

Regular Powder (40mesh)
*D50:85-185μm
checked checked checked checked checked checked checked checked
Fine Powder (100mesh)
*D50:80-110μm
checked checked checked checked
Super Fine Powder (300mesh)
*D50:20μm
checked

Application

Film Coating
Binding
Modified Release
* Particle size range is for reference purposes only
✝ Unique Ingredient Identifier (UNII) as established by U.S. FDA for identification of pharmaceutical ingredients.
Please Scroll Right arrow_forward

Introduction

NISSO HPC is the leading pharmaceutical excipient in Japan and used in over 3,000 marketed drugs worldwide. NISSO (Nippon Soda Co.,Ltd) has 45 years experience and technical expertise for manufacturing premium quality, silica-free HPC that meets the highest standards of the pharmaceutical market. NISSO HPC is available in a wide range of viscosities and particle size formats to achieve the most desirable excipient functionality for your application:

  • Regular Powder
    Regular Powder type HPC is mainly used in solution form. As a binder for wet granulation applications, low viscosity grades of HPC give an excellent balance of properties to oral solid dosage tablets by imparting superior strength and elegance without compromise of the disintegration profile. When used as a film coating agent, HPC improves film flexibility, elongation, and adhesion to the tablet.
  • Fine Powder
    Fine Powder type HPC has better formability than Regular Powder type and is mainly used in dry powder form. Having good wettability, lower viscosity grades are used as a dry-mix binder in high shear mixer formulations. Higher viscosity grades of HPC are applicable to controlled release matrix tablet formulations by direct compression application and give better release profiles compared to other common  CR polymers.
  • Super Fine Powder
    SFP grade offers the highest level of formability. Excellent tablet properties can be obtained at low use level in direct compression applications. SFP is applicable to poorly compressible drug and high drug load formulations. Additionally, excellent tablet properties can be achieved in orally disintegration tablet (ODT) formulations by direct compression method when SFP grade is used in combination with a super disintegrator.